Cerebral vein thrombosis associated with MTHFR A1289C mutation gene in a young postpartum woman

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Published Apr 13, 2019
DOI: https://doi.org/10.22551/2019.22.0601.10150
Alexandru Bostan Laura Cătălina Țăpoi Marian Nicolae Barcan Laura Florea

Abstract

Cerebral venous thrombosis is a rare cerebrovascular disease that accounts for approximately 1% of strokes, with an incidence of 3-4 cases / million inhabitants per year, with a significant mortality rate of 10-13%. Pregnancy and puerperal period are physiological states that predispose to thrombosis through hypercoagulability due to hormonal change. These alterations occur in blood flow, vascular wall and clotting factors and while superimposed on a genetically predisposing field, create the optimal conditions for the occurrence of embolic phenomena. Here we present the case of a young, secondipara woman with recurrent thrombotic events, even under optimal anticoagulation therapy, where the extensive laboratory investigations identified the predisposing terrain: the heterozygous mutation of the MTHFR A1289C gene.

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Keywords

cerebral venous thrombosis, pregnancy, thrombophilia, MTHFR A1289C

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How to Cite
Bostan, A., Țăpoi, L. C., Barcan, M. N., & Florea, L. (2019). Cerebral vein thrombosis associated with MTHFR A1289C mutation gene in a young postpartum woman. Archive of Clinical Cases, 6(1), Arch Clin Cases 2019; 6(1):26-30. https://doi.org/10.22551/2019.22.0601.10150
Issue
Vol. 6 No. 1 (2019)
Section
Case Reports

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How to Cite

Bostan, A., Țăpoi, L. C., Barcan, M. N., & Florea, L. (2019). Cerebral vein thrombosis associated with MTHFR A1289C mutation gene in a young postpartum woman. Archive of Clinical Cases, 6(1), Arch Clin Cases 2019; 6(1):26-30. https://doi.org/10.22551/2019.22.0601.10150