Spontaneous thrombosis of a giant cavernous-carotid aneurysm with simultaneous ipsilateral complete parent artery occlusion: a rare phenomenon and review of the literature
Abstract
Cavernous-carotid artery (CCA) aneurysms represent about 3-5% of all intracranial aneurysms. Spontaneous thrombosis of a CCA aneurysm with simultaneous occlusion of its parent vessel is an extremely rare phenomenon with few reported cases in the literature offering different management strategies. A 54-year-old Asian female presented with a one day-history of painless left eye conjunctival injection, proptosis, and features of cavernous sinus syndrome (cranial nerve III, IV, V1, V2, and VI palsies). Imaging revealed a giant thrombosed CCA aneurysm measuring 3.6cmx3.4cm with complete thrombosis of the left cervical internal carotid artery (ICA) and adequate collaterals from the anterior and posterior communicating artery and branches of the left external carotid artery. Management was conservative with antiplatelet therapy and close clinical-radiological follow-ups. The outcome was satisfactory. Data in the literature on this condition is limited due to its exceedingly rare occurrence. The majority of patients do well via a conservative approach and surgery is rarely indicated. For clinically stable patients, especially those with adequate collateral circulation and tolerance to Balloon Test Occlusion, we advocate for a conservative approach and initiation of anti-platelet therapy to treat these patients. Emphasis is needed on close serial clinicalradiological surveillance in these cases to monitor the propagation of the thrombus as well as the development of new and/or enlarging pre-existing aneurysms in the contralateral ICA circulation.
##plugins.themes.bootstrap3.article.details##
Cavernous-carotid artery, cavernous sinus syndrome, giant aneurysm, internal carotid artery thrombosis
2. Sastri SB, Sadasiva N, Pandey P. Giant cavernous carotid aneurysm with spontaneous ipsilateral ICA occlusion: Report of 2 cases and review of literature. J Neurosci Rural Pract. 2013;4(Suppl 1):S113-6. doi: 10.4103/0976-3147.116439. PMID: 24174776; PMCID: PMC3808038.
3. Menon G, Pradhan A, Hegde A. Spontaneous thrombosis of internal carotid artery with occlusion of giant cavernous carotid aneurysm and malignant hemispheric infarct–Cure or curse? J Cerebrovasc Sci. 2021; 9(2):103-105. doi: 10.4103/jcvs.jcvs_23_21
4. Dehdashti AR, de Tribolet N. Giant intracavernous aneurysm thrombosis by spontaneous carotid occlusion. Cerebrovasc Dis. 2003 ; 15(4):301-302. https://doi.org/10.1159/000069494
5. Linskey ME, Sekhar LN, Hirsch WL Jr, Yonas H, Horton JA. Aneurysms of the intracavernous carotid artery: natural history and indications for treatment. Neurosurgery. 1990;26(6):933-7; discussion 937-8. PMID: 2362671.
6. Lv X, Jiang C, Li Y, et al. Treatment of giant intracranial aneurysms. Interv Neuroradiol. 2009;15(2):135-44. doi: 10.1177/159101990901500201. PMID: 20465907; PMCID: PMC3299013.
7. Das KK, Singh G, Pandey S, Bhaisora KS, Jaiswal A, Behari S. Completely Thrombosed Giant Intracranial Aneurysm with Spontaneous Thrombosis of the Parent Artery: Is It Nature's Divine Intervention and a Self-Cure? World Neurosurg. 2018;118:132-138. doi: 10.1016/j.wneu.2018.07.072. PMID: 30026148.
8. Fomenko A, Kaufmann AM. Spontaneous Thrombosis of an Unruptured Saccular Aneurysm Causing MCA Infarction. Can J Neurol Sci. 2016;43(6):856-858. doi: 10.1017/cjn.2016.282. PMID: 27827296.
9. Brownlee RD, Tranmer BI, Sevick RJ, Karmy G, Curry BJ. Spontaneous thrombosis of an unruptured anterior communicating artery aneurysm. An unusual cause of ischemic stroke. Stroke. 1995;26(10):1945-1949. doi: 10.1161/01.str.26.10.1945. PMID: 7570753.
10. de Aguiar GB, Pagotto MV, Conti ML, Veiga JC. Spontaneous thrombosis of giant intracranial aneurysm and posterior cerebral artery followed by also spontaneous recanalization. Surg Neurol Int. 2016;7:15. doi: 10.4103/2152-7806.175898. PMID: 26958421; PMCID: PMC4766803.
11. Yamagami K, Hatano T, Ando M, et al. Symptomatic Cavernous Internal Carotid Artery Aneurysm Complicated by Simultaneous Rapid Growth of the Intra-aneurysmal and Parent Artery Thromboses. NMC Case Rep J. 2021;8(1):177-182. doi: 10.2176/nmccrj.cr.2020-0090. PMID: 35079460; PMCID: PMC8769381.
12. Tsutsumi M, Kazekawa K, Tanaka A, Ueno Y, Nomoto Y. Spontaneous thrombosis of a giant intracavernous internal carotid artery aneurysm and ipsilateral internal carotid artery occlusion. Radiat Med. 2002;20(5):261-263. PMID: 12450106.
13. Sato K, Fujiwara S, Yoshimoto T, Onuma T. Two cases of spontaneous internal carotid artery occlusion due to giant intracranial carotid artery aneurysm. Stroke. 1990;21(10):1506-9. doi: 10.1161/01.str.21.10.1506. PMID: 2219219.
14. Kurokawa R, Kuroshima Y, Yoshida K, Kawase T. Spontaneous thrombosis of intracavernous internal carotid artery aneurysm and parent artery occlusion in patients with positive balloon test occlusion--two case reports. Neurol Med Chir (Tokyo). 2001;41(9):436-441. doi: 10.2176/nmc.41.436. PMID: 11593970.
15. Whittle IR, Williams DB, Halmagyi GM, Besser M. Spontaneous thrombosis of a giant intracranial aneurysm and ipsilateral internal carotid artery. Case report. J Neurosurg. 1982;56(2):287-289. doi: 10.3171/jns.1982.56.2.0287. PMID: 7054441.
16. Perrini P, Bortolotti C, Wang H, Fraser K, Lanzino G. Thrombosed giant intracavernous aneurysm with subsequent spontaneous ipsilateral carotid artery occlusion. Acta Neurochir (Wien). 2005;147(2):215-6; discussion 216-217. doi: 10.1007/s00701-004-0403-4. PMID: 15605203.
17. Ray A, Leach P, Vafidis J. Spontaneous thrombosis of a giant internal carotid aneurysm in a patient who presented with hypopituitarism. Br J Neurosurg. 2002;16(6):590-592. PMID: 12617242.
18. Sastri SB, Sadasiva N, Pandey P. Giant cavernous carotid aneurysm with spontaneous ipsilateral ICA occlusion: Report of 2 cases and review of literature. J Neurosci Rural Pract. 2013;4(Suppl 1):S113-6. doi: 10.4103/0976-3147.116439. PMID: 24174776; PMCID: PMC3808038.
19. Mikabe T, Ogihara R, Tomita S, et al. No shinkei geka. Neurol surg. 1980; 8(8):749–753.
20. Gautier JC, Awada A, Majdalani A. Ophthalmoplegia with contralateral hemiplegia. Occlusion of the internal carotid artery due to thrombosis of an intracavernous aneurysm. Stroke. 1986;17(6):1321-2. doi: 10.1161/01.str.17.6.1321. PMID: 3810738.
21. Vasconcellos LP, Flores JA, Conti ML, Veiga JC, Lancellotti CL. Spontaneous thrombosis of internal carotid artery: a natural history of giant carotid cavernous aneurysms. Arq Neuropsiquiatr. 2009;67(2A):278-283. doi: 10.1590/s0004-282x2009000200020. PMID: 19547823.
22. Lv X, Jiang C, Li Y, Yang X, Zhang J, Wu Z. Treatment of giant intracranial aneurysms. Interv Neuroradiol. 2009;15(2):135-44. doi: 10.1177/159101990901500201. Epub 2009 Sep 1. PMID: 20465907; PMCID: PMC3299013.
23. Rosta L, Battaglia R, Pasqualin A, Beltramello A. Italian cooperative study on giant intracranial aneurysms: 2. Radiological data. Acta neurochir. Suppl. 1988; 42:53–59. https://doi.org/10.1007/978-3-7091-8975-7_11
24. Fomenko A, Kaufmann AM. Spontaneous Thrombosis of an Unruptured Saccular Aneurysm Causing MCA Infarction. Can J Neurol Sci. 2016;43(6):856-858. doi: 10.1017/cjn.2016.282. PMID: 27827296.
25. Brownlee RD, Tranmer BI, Sevick RJ, Karmy G, Curry BJ. Spontaneous thrombosis of an unruptured anterior communicating artery aneurysm. An unusual cause of ischemic stroke. Stroke. 1995;26(10):1945-9. doi: 10.1161/01.str.26.10.1945. PMID: 7570753.
26. Nguyen-Huynh MN, Lev MH, Rordorf G. Spontaneous recanalization of internal carotid artery occlusion. Stroke. 2003;34(4):1032-4. doi: 10.1161/01.STR.0000060872.85874.33. PMID: 12637693.
27. Wang CM, Chang YM, Sung PS, Chen CH. Hypoperfusion Index Ratio as a Surrogate of Collateral Scoring on CT Angiogram in Large Vessel Stroke. J Clin Med. 2021;10(6):1296. doi: 10.3390/jcm10061296. PMID: 33801050; PMCID: PMC8003946.
Archive of Clinical Cases is protected by copyright and may be used in accordance with copyright and other applicable laws. Content available at www.clinicalcases.eu and our digital applications is intended for personal noncommercial use.
Authors who submit a manuscript for publication in Archive of Clinical Cases agree to the following terms: a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) only after the final version of the manuscript was accepted and published, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). d. It is compulsory that before submission authors ensure that their work was not published in any other medical journals or pending acceptance for publication and that "Archives of Clinical Cases" is the only beneficiary at that moment if their work/case will be accepted by us.
Guidelines for linking to www.clinicalcases.eu a. The main purpose of the site linking to the Archive of Clinical Casess site should be educational. b. Links should be made to the Archive of Clinical Casess home page (www.clinicalcases.eu) or to the articles abstract. c. It is forbidden to use the Archive of Clinical Casess cover by outside organizations unless permission has been granted in advance, notifying our Secretary. d. Material owned by the Archive of Clinical Cases (including the name, logo, cover, and text) may not be used in any manner that may induce the idea or suggest that the Archive of Clinical Cases is in some way recommending a specific company, product or service. e. You must not use or allow others to access or use, all or any part of our Site or the contents and/or applications on it for commercial purposes without our permission. To seek permission to do anything prohibited by or not contained in these TERMS, or which requires our prior consent or agreement, you can contact us.